Doltrix which you can read about, including here https://pillintrip.com/medicine/doltrix is a medicine made up of two substances:
Butylhioscine: derived from scopolamine (a substance found in solanaceous plants), it has antispasmodic muscle activity, consequently, it decreases the sudden, involuntary and persistent contraction of muscle fibers.
Lysine clonixinate: a drug belonging to the group of non-steroidal anti-inflammatory drugs and analgesics, it inhibits the sensitization of pain receptors and cyclooxygenases (substances that help transport electrical pain signals to the brain), as a result, it reduces pain.
Doltrix is indicated for the management of the following conditions:
Genitourinary origin: renal colic, urolithiasis, bladder colic, orchiepididymitis (pain in the testicles), cramps due to menstruation.
Gastrointestinal origin: gallstones, cholecystitis (inflammation of the gallbladder), irritable colon.
Post-surgical pain: in gynecological and urological surgical procedures and also in general surgery.
Musculoskeletal: sprains, fractures.
Doltrix injectable solution can be used intravenously and/or intramuscularly. When used intravenously, it should be diluted at least in 20 ml and administered slowly.
The recommended doses should not be exceeded; in case of overdosage, gastric lavage should be performed.
The package should be kept at room temperature, no higher than 30°C.
Abundant water should be consumed because the components of Doltrix are excreted through the kidneys, and because it is rapidly absorbed orally.
Medication in children: Doltrix should not be used in children under 12 years of age, since its safety and efficacy have not been proven in this age group.
Presentations and forms of administration
Maver laboratory markets Doltrix in the following presentations:
Tablets: 250 mg of Lysine Clonixinate + 10 mg of Butylhioscine. Box with 10 tablets.
Injectable solution: 2 mL (20 mg of Butylhioscine + 100 mg of Lysine Clonixinate). Box with 3 ampoules.
Contraindications and Warnings
General: it is contraindicated in patients suffering from peptic ulcer, gastrointestinal bleeding, thyrotoxicosis (syndrome due to an excessive amount of thyroid hormones), heart failure, acute abdomen, glaucoma (optic nerve dysfunction), urinary tract obstruction. Special care should be taken with people suffering from intestinal obstruction and cardiac arrhythmias.
Allergies: do not prescribe or administer if allergic to Lysine Clonixinate or Butylhioscine.
Mixing with alcohol: alcohol decreases the effects of the active components of Doltrix.
Mixed with other drugs: amitriptyline, amoxapine, desipramine, doxepin, imipramine, quinine, amantadine, oseltamivir, zanamivir, zyrtec, clarinez, allegra, loratadine, haloperidol, droperidol, chlorpromazine, promazine increase the effect of Doltrix.
Doltrix is not compatible, has a medium risk and cannot be used during pregnancy. The page of the Faculty of Medicine of the UNAM suggests that it should not be administered during this stage, since the effects it may have on the fetus have not been proven with studies.
Doltrix is not compatible, has a medium risk and can be used during the breastfeeding period. The specialized portal e-lactancia.org mentions that there are no published data showing whether the components of Doltrix are excreted through breast milk, however, the passage of Doltrix (Butylhioscine + Lysine Clonixinate) through milk is unlikely, since it has a short half-life in the human organism, however, its use should be assessed by a medical specialist.
Gastrointestinal system: vomiting, diarrhea, constipation, abdominal pain, blood in feces.
Central nervous system: dizziness, drowsiness, dry mouth and throat, vertigo, fever.
Cardiovascular system: tachycardia, hypotension
Eyes: blurred vision, dilation of pupils
Muscular: pain at the site of application, either intramuscular or intravenous
Respiratory system: shortness of breath
Urinary: urinary retention
Skin: redness, itching, fluid-filled blisters
If you present one or more of the symptoms described above, you should consult a medical specialist and discontinue Doltrix immediately.