Pharmacological action of polygot

Polygot is a combined antimigraine drug. Pharmacological action is antimigraine. The effect of Polygot is associated with the vasoconstrictor effect of ergotamine and improvement of brain functions under the influence of caffeine. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates absorption of ergotamine and enhances the effect of ergot alkaloids in treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly in the cerebral cortex, respiratory and vasomotor centers. It increases mental and physical performance, reduces sleepiness and fatigue. Caffeine has a pronounced cardiotonic effect: it increases strength and heart rate, increases BP in hypotension.

Indications for the drug Polygot

  • vasoparalytic form of migraine;
  • arterial hypotension;
  • as a means of lowering intracranial pressure in vascular, traumatic and infectious lesions of the central nervous system.
Pharmacological action of polygot

Contraindications: Hypersensitivity to components of Polygote; Decompensated diseases of the cardiovascular system, marked hypertension or atherosclerosis; pregnancy; lactation. With caution (relative contraindications): sleep disorders; hyperexcitability;
anxiety disorders (agoraphobia, panic disorder);
organic diseases of the cardiovascular system (myocardial infarction, angina pectoris, atherosclerosis, paroxysmal tachycardia, ventricular extrasystole, arterial hypertension, obliterating diseases of peripheral vessels); hepatic and/or renal insufficiency; glaucoma (increase in intraocular pressure); advanced age.


Symptoms: restlessness, nervousness, irritability, insomnia, flushed face, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertension, confusion, hyperreflexia, numbness in fingers and toes, epileptic seizures.
Treatment: withdrawal of Polygote, gastric lavage, prescription of activated charcoal, if necessary – symptomatic therapy; beta-adrenoblockers (propranololol) prevent cardiotoxic effect and normalize blood pressure.

Special Directions. A physician should be consulted before using Polygote. Care should be taken to avoid an overdose of Polygote. Prolonged use of Polygote is not recommended.

Pharmacological action of polygot

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